Sioux Lookout is accessible by highway, railway, and airport.
The major arterial highways serving the region:
- Highway 72 runs southwest to northeast and links Sioux Lookout south to Highway 17 at Dinorwic, and north to Highway 599, via Highway 516.
- Highway 642 runs southeast and connects Sioux Lookout to Highway 599 at Silver Dollar.
- Highway 17, 69kms from Sioux Lookout, runs west to east and connects Dryden and Thunder Bay.
VIA Rail Passenger Service is available in Sioux Lookout. VIA Rail has a designated stop in Sioux Lookout six days per week. Stop-overs are generally 20 to 30 minutes in length.
CN is a leader in the North American rail industry. Following its acquisition of Illinois Central in 1999, WC in 2001 and GLT in 2004, as well as its partnership agreement with BC Rail in 2004, CN provides shippers with more options and greater reach in the rapidly expanding market for north-south trade.
The Sioux Lookout Airport is licensed as a public aerodrome and caters to the ever increasing demand of scheduled flights.
The airlines that are currently operating at the Airport are Bearskin Airlines and Wasaya Airways.
Charter flights are offered by Skycare, Bamaji Air, Superior Airways, Slate Falls Airway and Thunder Air.